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5am Venture Management, Llc

13F Holdings
Filed: 2025-05-15
Portfolio Value
264.41M arrow_downward -36.9%
Number of Holdings
lock info
Reporting Date
2025-03-31
Key Stats trending_flat
CIK
0001799883
Filing Date
2025-05-15 16:01:07
Address
4 Embarcadero Center, Suite 3110
San Francisco
CA
Prior Value
419.05M
Top 10 Holdings %
lock
Portfolio Value
5am Venture Management, Llc
(13F - 2025-03-31)
Entrada Therapeutics Inc
-
2025-05-15
Value
39.85M
Shares
4.41M
Portfolio %
15.07%
Enliven Therapeutics Inc
-
2025-05-15
Value
26.03M
Shares
1.32M
Portfolio %
9.84%
Dianthus Therapeutics Inc
-
2025-05-15
Value
18.64M
Shares
1.03M
Portfolio %
7.05%
Skye Bioscience Inc
-
2025-05-15
Value
15.76M
Shares
9.91M
Portfolio %
5.96%
Pharvaris N V
-
2025-05-15
Value
12.52M
Shares
797.60K
Portfolio %
4.74%
Centessa Pharmaceuticals Plc
CNTA
2025-05-15
Value
11.95M
Shares
830.95K
Portfolio %
4.52%
Camp4 Therapeutics Corp
CAMP
2025-05-15
Value
11.71M
Shares
2.93M
Portfolio %
4.43%
Biohaven Ltd
BHVN
2025-05-15
Value
11.51M
Shares
478.97K
Portfolio %
4.35%
Moonlake Immunotherapeutics
MLTX
2025-05-15
Value
11.03M
Shares
282.31K
Portfolio %
4.17%
Viridian Therapeutics Inc
-
2025-05-15
Value
9.93M
Shares
736.60K
Portfolio %
3.76%
Top Increases | 5am Venture Management, Llc
(2024-12-31 → 2025-03-31)
Dianthus Therapeutics Inc
-
2025-05-15
Value Change
arrow_upward -3761422.00
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 1.70%
Portfolio %
7.05%
Gh Research Plc
GHRS
2025-05-15
Value Change
arrow_upward 2.31M
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 1.43%
Portfolio %
2.39%
Anaptysbio Inc
-
2025-05-15
Value Change
arrow_upward 1.91M
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 1.38%
Portfolio %
2.52%
Centessa Pharmaceuticals Plc
CNTA
2025-05-15
Value Change
arrow_upward -1969340.00
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 1.20%
Portfolio %
4.52%
Enliven Therapeutics Inc
-
2025-05-15
Value Change
arrow_upward -10643366.00
Shares
arrow_upward -307288.00
Portfolio % Change
arrow_upward 1.09%
Portfolio %
9.84%
Pharvaris N V
-
2025-05-15
Value Change
arrow_upward -2767672.00
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 1.09%
Portfolio %
4.74%
Camp4 Therapeutics Corp
CAMP
2025-05-15
Value Change
arrow_upward -3572056.00
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 0.78%
Portfolio %
4.43%
Moonlake Immunotherapeutics
MLTX
2025-05-15
Value Change
arrow_upward -4257280.00
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 0.52%
Portfolio %
4.17%
Celldex Therapeutics Inc New
-
2025-05-15
Value Change
arrow_upward -3540562.00
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 0.41%
Portfolio %
3.41%
Viridian Therapeutics Inc
-
2025-05-15
Value Change
arrow_upward -4191225.00
Shares
arrow_upward 0.00
Portfolio % Change
arrow_upward 0.39%
Portfolio %
3.76%
Top Decreases | 5am Venture Management, Llc
(2024-12-31 → 2025-03-31)
Zentalis Pharmaceuticals Inc
-
2025-05-15
Value Change
arrow_downward -705600.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 0.06%
Portfolio %
0.29%
Viking Therapeutics Inc
-
2025-05-15
Value Change
arrow_downward -3050551.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 0.09%
Portfolio %
1.73%
Silence Therapeutics Plc
SLNCF
2025-05-15
Value Change
arrow_downward -1933372.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 0.27%
Portfolio %
0.51%
Mersana Therapeutics Inc
-
2025-05-15
Value Change
arrow_downward -1416969.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 0.28%
Portfolio %
0.17%
Erasca Inc
-
2025-05-15
Value Change
arrow_downward -6162161.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 0.44%
Portfolio %
2.80%
Praxis Precision Medicines I
-
2025-05-15
Value Change
arrow_downward -6645300.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 0.69%
Portfolio %
2.43%
Skye Bioscience Inc
-
2025-05-15
Value Change
arrow_downward -12292328.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 0.73%
Portfolio %
5.96%
Artiva Biotherapeutics Inc
-
2025-05-15
Value Change
arrow_downward -16661392.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 2.99%
Portfolio %
2.67%
Entrada Therapeutics Inc
-
2025-05-15
Value Change
arrow_downward -36369127.00
Shares
arrow_downward 0.00
Portfolio % Change
arrow_downward 3.12%
Portfolio %
15.07%
Tectonic Therapeutic Inc
-
2025-05-15
Value Change
arrow_downward -18486293.00
Shares
arrow_downward -85000.00
Portfolio % Change
arrow_downward 3.15%
Portfolio %
3.43%
5am Venture Management, Llc (13F - 2025-03-31) Comparing to 2024-12-31
New/Increased Position added or increased from previous period Closed/Decreased Position closed or decreased from previous period
arrow_upward Increase arrow_downward Decrease
Company Ticker Type Shares Value Current % Previous % % Change $ Change $ Change % Shares Change Status Qtr End Price Filing Date
New Positions | 5am Venture Management, Llc
(2024-12-31 → 2025-03-31)
Surrozen Inc
-
2025-05-15
Value
add_circle 3.61M
Shares
310.00K
Portfolio %
1.37%
% Change
1.37%
Closed Positions | 5am Venture Management, Llc
(2024-12-31 → 2025-03-31)
Akero Therapeutics Inc
-
2025-02-14
Value
remove_circle 4.59M
Shares
165.00K
Previous %
18.19%
% Change
-18.19%